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Article

Pax3 target gene recognition occurs through distinct modes that are differentially affected by disease-associated mutations.

Pigment cell research - 1 Dec 2005

Corry Gareth N, Underhill D Alan

Abstract excerpt

The paired box protein Pax3 is an essential regulator of muscle and neural crest-derived cell types, including melanocytes. Within this lineage, Pax3 has been shown to regulate the genes encoding microphthalmia-associated transcription factor (Mitf) and tyrosinase-related protein-1 (Trp-1), despite each having dissimilar Pax3 recognition sequences. We have, therefore, examined the structural requirements for Pax3...

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Source

Identifiers

PMID: 16280008
DOI: 10.1111/j.1600-0749.2005.00275.x

Genes

MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pax3 target gene recognition occurs through distinct modes that are differentially affected by disease-associated mutations.PMID 16280008Read ↗

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