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Article

Mutational analysis of the Acropora millepora PaxD paired domain highlights the importance of the linker region for DNA binding.

Gene - 27 Nov 2003

Nordström Karin, Scholten Ingo, Nordström Johanna, Larhammar Dan, Miller David

Abstract excerpt

Pax transcription factors are found in animals, from simple sponges to insects and vertebrates. The defining feature of Pax proteins is the DNA-binding paired domain (PD), which consists of two helix-turn-helix subdomains, joined with a linker region. Despite high specificity in vivo, the paired domains of different Pax proteins bind similar consensus DNA sequences in vitro. Using bandshift techniques, we show...

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Source

Identifiers

PMID: 14597391
DOI: 10.1016/s0378-1119(03)00812-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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