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Article

The genetic association of the transcription factor NPAT with glycemic response to metformin involves regulation of fuel selection.

PloS one - 1 Jan 2021

Chen Changwei, Gallagher Jennifer R, Tarlton Jamie, van Aalten Lidy, Bray Susan E, Ashford Michael L J, McCrimmon Rory J, Pearson Ewan R, McNeilly Alison D, Sutherland Calum

Abstract excerpt

The biguanide, metformin, is the first-choice therapeutic agent for type-2 diabetes, although the mechanisms that underpin metformin clinical efficacy remain the subject of much debate, partly due to the considerable variation in patient response to metformin. Identification of poor responders by genotype could avoid unnecessary treatment and provide clues to the underlying mechanism of action. GWAS identified...

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Identifiers

PMID: 34197485
DOI: 10.1371/journal.pone.0253533
PMCID: PMC8248654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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