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Article

Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype.

Clinical science (London, England : 1979) - 29 Oct 2021

Wilson Laura, Pollard Alice E, Penfold Lucy, Muckett Phillip J, Whilding Chad, Bohlooly-Y Mohammad, Wilson Patricia, Carling David

Abstract excerpt

AMP-activated protein kinase (AMPK) plays a key role in the cellular response to low energy stress and has emerged as an attractive therapeutic target for tackling metabolic diseases. Whilst significant progress has been made regarding the physiological role of AMPK, its function in the kidney remains only partially understood. We use a mouse model expressing a constitutively active mutant of AMPK to investigate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34622923
DOI: 10.1042/CS20210821

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