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Article

Folliculin regulates ampk-dependent autophagy and metabolic stress survival.

PLoS genetics - 1 Apr 2014

Possik Elite, Jalali Zahra, Nouët Yann, Yan Ming, Gingras Marie-Claude, Schmeisser Kathrin, Panaite Lorena, Dupuy Fanny, Kharitidi Dmitri, Chotard Laëtitia, Jones Russell G, Hall David H, Pause Arnim

Abstract excerpt

Dysregulation of AMPK signaling has been implicated in many human diseases, which emphasizes the importance of characterizing AMPK regulators. The tumor suppressor FLCN, responsible for the Birt-Hogg Dubé renal neoplasia syndrome (BHD), is an AMPK-binding partner but the genetic and functional links between FLCN and AMPK have not been established. Strikingly, the majority of naturally occurring FLCN mutations...

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Identifiers

PMID: 24763318
DOI: 10.1371/journal.pgen.1004273
PMCID: PMC3998892

Genes

FLCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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