Article

Ampk alpha2 T172 Activation Dictates Exercise Performance and Energy Transduction in Skeletal Muscle

2025-09-22

Abstract excerpt

<h4>SUMMARY</h4> AMPK (5′-AMP-activated protein kinase) is an energetic sensor for metabolic regulation and integration. Here, we employed CRISPR/Cas9 to generate non-activatable Ampkα knock-in (KI) mice with mutation of threonine 172 phosphorylation site to alanine, circumventing the limitations of previous genetic interventions that disrupt the protein stoichiometry. KI mice of Ampkα2, but not Ampkα1, demonstra...

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Literature Corpus work: a253fd96-0a14-50fa-941d-38a9e234dcab
DOI: 10.1101/2025.09.22.677805

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