Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Physiological Expression of AMPKγ2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice.

The Journal of biological chemistry - 4 Nov 2016

Yang Xiaodong, Mudgett John, Bou-About Ghina, Champy Marie-France, Jacobs Hugues, Monassier Laurent, Pavlovic Guillaume, Sorg Tania, Herault Yann, Petit-Demoulière Benoit, Lu Ku, Feng Wen, Wang Hongwu, Ma Li-Jun, Askew Roger, Erion Mark D, Kelley David E, Myers Robert W, Li Cai, Guan Hong-Ping

Abstract excerpt

Mutations of the AMP-activated kinase gamma 2 subunit (AMPKγ2), N488I (AMPKγ2NI) and R531G (AMPKγ2RG), are associated with Wolff-Parkinson-White (WPW) syndrome, a cardiac disorder characterized by ventricular pre-excitation in humans. Cardiac-specific transgenic overexpression of human AMPKγ2NI or AMPKγ2RG leads to constitutive AMPK activation and the WPW phenotype in mice. However, overexpression of these mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinases
Share to Apoptosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Gene Knock-In Techniques

Share to Inflammation

Share to Kidney

Share to Mice, Inbred C57BL

Share to Renal Insufficiency

Source

Open in PubMed Open full text

Identifiers

PMID: 27621313
DOI: 10.1074/jbc.M116.738591
PMCID: PMC5095399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Physiological Expression of AMPKγ2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice.PMID 27621313Read ↗

Molecular Pathogenesis of Familial Wolff-Parkinson-White Syndrome.Semantic proximity Read ↗

Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome.Semantic proximity Read ↗

A PRKAG2 mutation causes biphasic changes in myocardial AMPK activity and does not protect against ischemia.Semantic proximity Read ↗

Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome.Semantic proximity Read ↗

Glycogen storage disease as a unifying mechanism of disease in the PRKAG2 cardiac syndrome.Semantic proximity Read ↗

Fine-tuning AMPK in physiology and disease using point-mutant mouse modelsSemantic proximity Read ↗

Human γ2-AMPK Mutations.Semantic proximity Read ↗

Familial Wolff-Parkinson-White Syndrome: a disease of glycogen storage or ion channel dysfunction?Semantic proximity Read ↗

Gain of function AMP-activated protein kinase γ3 mutation (AMPKγ3R200Q) in pig muscle increases glycogen storage regardless of AMPK activation.Semantic proximity Read ↗

Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype.Semantic proximity Read ↗

The AMPK gamma1 R70Q mutant regulates multiple metabolic and growth pathways in neonatal cardiac myocytes.Semantic proximity Read ↗

Metabolic functions of AMPK: aspects of structure and of natural mutations in the regulatory gamma subunits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.