Article
Metformin induces the AP-1 transcription factor network in normal dermal fibroblasts
29 Mar 2019
Abstract excerpt
Metformin is a widely-used treatment for type 2 diabetes and is reported to extend health and lifespan as a caloric restriction (CR) mimetic. Although the benefits of metformin are well documented, the impact of this compound on the function and organization of the genome in normal tissues is unclear. To explore this impact, primary human fibroblasts were treated in culture with metformin resulting in a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.