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Article

Genomic Characterization of Metformin Hepatic Response.

PLoS genetics - 1 Nov 2016

Luizon Marcelo R, Eckalbar Walter L, Wang Yao, Jones Stacy L, Smith Robin P, Laurance Megan, Lin Lawrence, Gallins Paul J, Etheridge Amy S, Wright Fred, Zhou Yihui, Molony Cliona, Innocenti Federico, Yee Sook Wah, Giacomini Kathleen M, Ahituv Nadav

Abstract excerpt

Metformin is used as a first-line therapy for type 2 diabetes (T2D) and prescribed for numerous other diseases. However, its mechanism of action in the liver has yet to be characterized in a systematic manner. To comprehensively identify genes and regulatory elements associated with metformin treatment, we carried out RNA-seq and ChIP-seq (H3K27ac, H3K27me3) on primary human hepatocytes from the same donor...

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Source

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Identifiers

PMID: 27902686
DOI: 10.1371/journal.pgen.1006449
PMCID: PMC5130177

Genes

ATM
ATF3
DDX10
EXPH5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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