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Article

Adipocyte-specific inactivation of NAMPT, a key NAD+ biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging.

American journal of physiology. Endocrinology and metabolism - 1 Jul 2024

Qi Nathan, Franczyk Michael P, Yamaguchi Shintaro, Kojima Daiki, Hayashi Kaori, Satoh Akiko, Ogiso Noboru, Kanda Takeshi, Sasaki Yo, Finck Brian N, DeBosch Brian J, Yoshino Jun

Abstract excerpt

Nicotinamide adenine dinucleotide (NAD+) is a universal coenzyme regulating cellular energy metabolism in many cell types. Recent studies have demonstrated the close relationships between defective NAD+ metabolism and aging and age-associated metabolic diseases. The major purpose of the present study was to test the hypothesis that NAD+ biosynthesis, mediated by a rate-limiting NAD+ biosynthetic enzyme,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38809511
DOI: 10.1152/ajpendo.00313.2023
PMCID: PMC11390120

Genes

NAMPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Adipocyte-specific inactivation of NAMPT, a key NAD+ biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging.PMID 38809511Read ↗

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