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Article

AMPK controls epithelial Na(+) channels through Nedd4-2 and causes an epithelial phenotype when mutated.

Pflugers Archiv : European journal of physiology - 1 Aug 2009

Almaça Joana, Kongsuphol Patthara, Hieke Bernhard, Ousingsawat Jiraporn, Viollet Benoit, Schreiber Rainer, Amaral Margarida D, Kunzelmann Karl

Abstract excerpt

The metabolic sensor adenosine-monophosphate-activated kinase (AMPK) detects the cellular energy status and adjusts metabolic activity according to the cytosolic AMP to ATP ratio. Na(+) absorption by epithelial Na(+) channels (ENaC) is a highly energy-consuming process that is inhibited by AMPK. We show that the catalytic subunit alpha1 of AMPK inhibits ENaC in epithelial tissues from airways, kidney, and colon...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19333618
DOI: 10.1007/s00424-009-0660-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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