Article

Mitochondrial activity directs nutrient uptake to control early human embryonic patterning

2026-05-22

Abstract excerpt

How a uniform field of cells responds to inductive cues to form distinct, spatially organised, lineages is a question of much interest. In human gastruloids, a BMP4 signalling gradient directs the self-organization of embryonic stem cells (hESCs) into the three germ-layers. But what regulates differential responses to BMP4 is poorly understood. Here we demonstrate that mitochondrial activity is key, as by directin...

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Literature Corpus work: e3d0528a-f0cd-5e89-844d-9db83d800837
DOI: 10.64898/2026.05.20.725854

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