Article
Regulatory T-cell phenotypes in children with sickle cell disease.
Pediatric research - 1 Apr 2022
Zahran Asmaa M, Saad Khaled, Elsayh Khalid I, Khalaf Shaimaa M, Mahmoud Khaled Hashim, Elhoufey Amira, Hetta Helal F
Abstract excerpt
BACKGROUND: Regulatory T cells (Tregs) are linked to a reduction in alloreactive immune responses, but few studies have investigated the impact of hydroxyurea (HU) therapy on Tregs in sickle cell disease (SCD). METHODS: Our case-controlled study presented here included two groups, the first comprising 60 pediatric SCD patients, 30 of whom did not receive any treatment and 30 who received HU, and the second group...
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