Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease.

Blood - 15 Oct 2005

Zorn Emmanuel, Kim Haesook T, Lee Stephanie J, Floyd Blair H, Litsa Despina, Arumugarajah Sankari, Bellucci Roberto, Alyea Edwin P, Antin Joseph H, Soiffer Robert J, Ritz Jerome

Abstract excerpt

Chronic graft-versus-host disease (cGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation but the immune mechanisms leading to the diverse clinical manifestations of cGVHD remain unknown. In this study, we examined regulatory T cells (Tregs) in 57 transplant recipients (30 with cGVHD and 27 without active cGVHD) and 26 healthy donors. Phenotypic studies demonstrated decreased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to Chronic Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Forkhead Transcription Factors

Share to Graft vs Host Disease

Share to Hematopoietic Stem Cell Transplantation

Share to Immunosuppression Therapy

Share to Receptors, Interleukin-2

Share to Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 15972448
DOI: 10.1182/blood-2005-03-1257
PMCID: PMC1895303

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease.PMID 15972448Read ↗

Regulatory T cell therapy for Graft-versus-Host DiseaseSemantic proximity Read ↗

Regulatory T cells in solid organ transplantationSemantic proximity Read ↗

Regulatory T Cell Therapy of Graft-versus-Host Disease: Advances and ChallengesSemantic proximity Read ↗

Blockade of chronic graft-versus-host disease by alloantigen-induced CD4+CD25+Foxp3+ regulatory T cells in nonlymphopenic hosts.Semantic proximity Read ↗

Acute but not chronic graft-versus-host disease is associated with a reduction of circulating CD4+CD25highCD127low/− regulatory T cellsSemantic proximity Read ↗

Analysis of the T-cell repertoire and transcriptome identifies mechanisms of regulatory T-cell suppression of GVHDSemantic proximity Read ↗

Frequency of CD4(+)CD25(hi)FOXP3(+) regulatory T cells has diagnostic and prognostic value as a biomarker for acute graft-versus-host-disease.Semantic proximity Read ↗

Integrated Analysis of T cell Repertoire and Transcriptome Identifies Mechanisms of Regulatory T cell (Treg) Suppression of Acute Graft-versus-Host-DiseaseSemantic proximity Read ↗

Human regulatory T cells in allogeneic stem cell transplantationSemantic proximity Read ↗

Regulatory T cells in acute and chronic kidney diseases.Semantic proximity Read ↗

Comparative analysis of FoxP3(+) regulatory T cells in the target tissues and blood in chronic graft versus host disease.Semantic proximity Read ↗

Low telomerase activity in CD4+ regulatory T cells in patients with severe chronic GVHD after hematopoietic stem cell transplantationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.