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Characterization of rabbit antithymocyte globulins-induced CD25+ regulatory T cells from cells of patients with end-stage renal disease.

Transplantation - 27 Mar 2010

Sewgobind Varsha D K D, van der Laan Luc J W, Kho Marcia M L, Kraaijeveld Rens, Korevaar Sander S, van Dam Thea, Ijzermans Jan N M, Weimar Willem, Baan Carla C

Abstract excerpt

BACKGROUND.: Rabbit antithymocyte globulins (rATGs) are known to convert CD4CD25FoxP3 T cells from healthy individuals to CD4CD25FoxP3 T cells. In this study, we investigated the effect of rATG on the induction of regulatory T cells (Tregs) from blood cells of patients with end-stage renal disease who are candidates for transplantation and rATG-induction therapy. The induced Tregs were analyzed and compared with...

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PMID: 20164820
DOI: 10.1097/TP.0b013e3181c9cc7a

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CTLA4

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