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Article

Altered T-Cell Profile in Sickle Cell Disease

1 Mar 2023

Abstract excerpt

Background: Impaired immune status due to altered T-cell response in sickle cell disease (SCD) might provide substantial insight into immune activity in SCD patients. Materials & methods: A total of 30 healthy control, 20 SCD patients in a crisis state and 38 SCD patients in a steady state were evaluated for T-cell subsets. Results: A significant decrease in CD8+ (p = 0.012) and CD8+45RA-197+ (p = 0.015) T-cells...

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PMID: 37204241
DOI: 10.2217/bmm-2023-0086

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