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Article

Partial dysfunction of Treg activation in sickle cell disease.

American journal of hematology - 1 Mar 2014

Vingert Benoît, Tamagne Marie, Desmarets Maxime, Pakdaman Sadaf, Elayeb Rahma, Habibi Anoosha, Bernaudin Françoise, Galacteros Frédéric, Bierling Philippe, Noizat-Pirenne France, Cohen José Laurent, Cohen José

Abstract excerpt

Sickle cell disease (SCD) is a chronic inflammatory disease associated with multiple organ damage, chronic anemia, and infections. SCD patients have a high rate of alloimmunization against red blood cells (RBCs) following transfusion and may develop autoimmune diseases. Studies in mouse models have suggested that regulatory T cells (Treg) play a role in alloimmunization against RBC antigens. We characterized the...

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Topics

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Share to Anemia, Sickle Cell
Share to Blood Group Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood Group Incompatibility

Share to CTLA-4 Antigen

Share to Erythrocytes

Share to HLA-DR Antigens

Share to Receptors, CCR7

Share to T-Lymphocytes, Regulatory

Source

Identifiers

PMID: 24779034
DOI: 10.1002/ajh.23629

Genes

SCD
CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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