Article
Phenotypic differences of CD4(+) T cells in response to red blood cell immunization in transfused sickle cell disease patients.
European journal of immunology - 1 Jun 2015
Vingert Benoît, Tamagne Marie, Habibi Anoosha, Pakdaman Sadaf, Ripa Julie, Elayeb Rahma, Galacteros Frédéric, Bierling Philippe, Ansart-Pirenne Hélène, Bartolucci Pablo, Noizat-Pirenne France
Abstract excerpt
Alloimmunization against red blood cells (RBCs) is the main immunological risk associated with transfusion in patients with sickle cell disease (SCD). However, about 50-70% of SCD patients never get immunized despite frequent transfusion. In murine models, CD4(+) T cells play a key role in RBC alloimmunization. We therefore explored and compared the CD4(+) T-cell phenotypes and functions between a group of SCD...
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