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Article

Maturation and Phenotypic Heterogeneity of Human CD4+ Regulatory T Cells From Birth to Adulthood and After Allogeneic Stem Cell Transplantation.

Frontiers in immunology - 1 Jan 2020

Matos Tiago R, Hirakawa Masahiro, Alho Ana C, Neleman Lars, Graca Luis, Ritz Jerome

Abstract excerpt

CD4+ Regulatory T cells (Treg) play a critical role in maintaining immune homeostasis. Various Treg subsets have been identified, however the heterogeneity of Treg subpopulations during development remains uncharacterized. Using mass cytometry we obtained single cell data on expression of 35 functional markers to examine the heterogeneity of Treg cells at birth and in adults. Unsupervised clustering algorithms...

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Identifiers

PMID: 33537026
DOI: 10.3389/fimmu.2020.570550
PMCID: PMC7848157

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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