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High proportions of regulatory T cells in PBSC grafts predict improved survival after allogeneic haematopoietic SCT

21 Sept 2015

Abstract excerpt

Regulatory T cells (Tregs) modulate immune responses and improve survival in murine transplant models. However, whether the Treg content of allogeneic cell grafts influences the outcome in human haematopoietic stem cell (HSC) transplantation is not well established. In a prospective study of 94 adult allogeneic PBSC transplants (60% unrelated; 85% reduced intensity conditioning), the median Treg...

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PMID: 26389831
DOI: 10.1038/bmt.2015.215

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