Article
Integrating Pathogenic Variants, Polygenic Risk Score, and Family History for Prostate Cancer Risk Estimation in Men of African Ancestry.
European urology - 1 May 2026
Chen Fei, Sheng Xin, Wang Anqi, Xu Yili, Hughley Raymond, Xiong Wei, Pooler Loreall, Wan Peggy, Gundell Susan M, Kigozi Godfrey, Nakigozi Gertrude, Nalugoda Fred, Kagaayi Joseph, Kigozi Grace Nalwoga, Mugamba Stephen, Kyasanku Emmanuel, Nkale James, Olwa Vitalis Ofumbi, Lubwama Alexander, Daama Alex, Nakajugo Resty, Adusei Ben, Jalloh Mohamed, Gueye Serigne Magueye, Adjei Andrew A, Mensah James, Fernandez Pedro W, Adebiyi Akindele Olupelumi, Olufemi Ogunbiyi J, Aisuodionoe-Shadrach Oseremen Inokhoife, Petersen Lindsay, Chen Wenlong Carl, McBride Jo, Bensen Jeannette T, Mohler James L, Taylor Jack A, Andrews Caroline, Kigongo Mbaaga, Colline Amanya, Kiddu Vicky, Namugambe Juliet, Owamaani Shallot, Job Kuteesa, Masaba Benon Joseph, Asiimwe Frank, Muwanga Proscovia, Namulondo Joy, Nagawa Florence, Kayiraba Charity, Ogwang Martin, Okidi Ronald, Oweka David, Kitara Elio, Obonyo James, Lajul Daniel, Matovu Paul, Muheki Precious Arinda, Natumanya Johnson, Agaba Emmanuel, Aculokin Emmanuel, Twongyeirwe Amos, Mutema George, Bitamazire Denis, Butler Eboneé N, Ingles Sue Ann, Rybicki Benjamin A, Stanford Janet L, Zheng Wei, Berndt Sonja I, Chanock Stephen J, Huff Chad D, Lachance Joseph, Multigner Luc, Darst Burcu F, Rebbeck Timothy R, Brureau Laurent, Watya Stephen, Conti David V, Haiman Christopher A
Abstract excerpt
BACKGROUND AND OBJECTIVE: The impact of germline pathogenic variants (PVs) in cancer predisposition genes on risk of prostate cancer (PCa) remains understudied in large populations of African ancestry. This study aims to characterize the range of genetic risk of PCa and aggressive disease phenotypes in men of African ancestry. METHODS: We analyzed 7176 PCa cases and 4873 controls from seven countries across North...
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