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Article

Genomic Sequencing and Insight into Clinical Heterogeneity and Prognostic Pathway Genes in Patients with Metastatic Colorectal Cancer.

Journal of the American College of Surgeons - 1 Aug 2021

Kawaguchi Yoshikuni, Kopetz Scott, Kwong Lawrence, Xiao Lianchun, Morris Jeffrey S, Tran Cao Hop S, Tzeng Ching-Wei D, Chun Yun Shin, Lee Jeffrey E, Vauthey Jean-Nicolas

Abstract excerpt

BACKGROUND: An understanding of signaling pathways has not been fully incorporated into prognostication and therapeutic options. We evaluated the hypothesis that information about cancer-related signaling pathways can improve prognostic stratification and explain some of the clinical heterogeneity in patients with metastatic colorectal cancer. STUDY DESIGN: We analyzed prognostic relevance of signaling pathways...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34111531
DOI: 10.1016/j.jamcollsurg.2021.05.027
PMCID: PMC8666966

Genes

APC
TP53
BRAF
KRAS
PIK3CA
RB1
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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