Article
Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes.
BMC cancer - 18 Dec 2025
Harrison Tabitha A, Zaidi Syed H, Yin Hang, Steinfelder Robert S, Qu Conghui, Aglago Elom K, Berndt Sonja I, Boardman Lisa A, Brenner Hermann, Buchanan Daniel D, Campbell Peter T, Cao Yin, Chan Andrew T, Chanock Stephen J, Doheny Kimberly F, Drew David A, Figueiredo Jane C, French Amy J, Gallinger Steven, Georgeson Peter, Giannakis Marios, Goode Ellen L, Gruber Stephen B, Gsur Andrea, Gunter Marc J, Harlid Sophia, Hoffmeister Michael, Huang Wen-Yi, Hullar Meredith Aj, Huyghe Jeroen R, Jenkins Mark A, Lin Yi, Moreno Victor, Murphy Neil, Newcomb Polly A, Newton Christina C, Nowak Jonathan A, Obón-Santacana Mireia, Ogino Shuji, Shelford Tameka, Song Mingyang, Thomas Claire E, Toland Amanda E, Ugai Tomotaka, Um Caroline Y, Van Guelpen Bethany, Trinh Quang M, Sun Wei, Hudson Thomas J, Hsu Li, Peters Ulrike, Phipps Amanda I
Abstract excerpt
BACKGROUND: Identifying significantly mutated genes in tumors aids in understanding disease etiology and survival and may aid in the discovery of new drug targets. We aimed to detect and characterize mutated genes from a large, well-characterized group of colorectal cancers. METHODS: In tumor and paired normal samples from 6,111 colorectal patients, we sequenced 199 genes identified from whole exome sequencing of...
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