Prognostic genome and transcriptome signatures in colorectal cancers.

doi:10.1038/s41586-024-07769-3

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Article

Prognostic genome and transcriptome signatures in colorectal cancers.

Nature - 1 Sept 2024

Nunes Luís, Li Fuqiang, Wu Meizhen, Luo Tian, Hammarström Klara, Torell Emma, Ljuslinder Ingrid, Mezheyeuski Artur, Edqvist Per-Henrik, Löfgren-Burström Anna, Zingmark Carl, Edin Sofia, Larsson Chatarina, Mathot Lucy, Osterman Erik, Osterlund Emerik, Ljungström Viktor, Neves Inês, Yacoub Nicole, Guðnadóttir Unnur, Birgisson Helgi, Enblad Malin, Ponten Fredrik, Palmqvist Richard, Xu Xun, Uhlén Mathias, Wu Kui, Glimelius Bengt, Lin Cong, Sjöblom Tobias

Abstract excerpt

Colorectal cancer is caused by a sequence of somatic genomic alterations affecting driver genes in core cancer pathways1. Here, to understand the functional and prognostic impact of cancer-causing somatic mutations, we analysed the whole genomes and transcriptomes of 1,063 primary colorectal cancers in a population-based cohort with long-term follow-up. From the 96 mutated driver genes, 9 were not previously...

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PMID: 39112715
DOI: 10.1038/s41586-024-07769-3
PMCID: PMC11374687

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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