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Article

Integrative genomic analysis identifies clinically relevant prognostic markers for colorectal cancer patients with liver metastasis.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Mar 2026

Li Wentao, Liu Ming, Wu Liula, Zhu Bosen, Li Xiangtao, Yang Ziyi, Liang Yi, Lin Junqiong

Abstract excerpt

PURPOSE: Colorectal liver metastases (CRLM) pose a significant clinical challenge due to their high recurrence rates, even after surgical resection. There is an urgent need for reliable prognostic biomarkers to improve risk stratification and guide treatment decisions for CRLM patients. METHODS/PATIENTS: In this study, we performed whole-exome sequencing (WES) on 57 CRLM patients and conducted a comparative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40880011
DOI: 10.1007/s12094-025-04021-w

Genes

APC
KRAS
MUC2
PIK3CA
SMAD4
TP53
ZNF717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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