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Integrative Genomic and Clinical Profiling of Colorectal Cancer Liver Metastases to Guide Personalized Surgery and Liver Transplantation.

Cancer genomics & proteomics - 1 Jan 2026

Moris Dimitrios, Nguyen Brian, Kroemer Alexander, Ziogas Ioannis A, Giannou Anastasios D, Fishbein Thomas M, Genyk Yuri S, Gupta Piyush

Abstract excerpt

BACKGROUND/AIM: Colorectal cancer liver metastases (CRLM) remain a leading cause of cancer-related mortality. Although hepatic resection is the only established curative option, recurrence exceeds 60%, underscoring substantial biologic heterogeneity. Liver transplantation (LT) has re-emerged for highly selected patients with unresectable CRLM, but optimal biologic selection criteria remain undefined. This study...

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Source

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Identifiers

PMID: 42373221
DOI: 10.21873/cgp.20592
PMCID: PMC13321708

Genes

BRAF
SMAD4
KRAS
NRAS
APC
PIK3CA
TP53

Provenance

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