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Article

Association between mutations of critical pathway genes and survival outcomes according to the tumor location in colorectal cancer.

Cancer - 15 Sept 2017

Lee Dae-Won, Han Sae-Won, Cha Yongjun, Bae Jeong Mo, Kim Hwang-Phill, Lyu Jaemyun, Han Hyojun, Kim Hyoki, Jang Hoon, Bang Duhee, Huh Iksoo, Park Taesung, Won Jae-Kyung, Jeong Seung-Yong, Park Kyu Joo, Kang Gyeong Hoon, Kim Tae-You

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) develops through the alteration of several critical pathways. This study was aimed at evaluating the influence of critical pathways on survival outcomes for patients with CRC. METHODS: Targeted next-generation sequencing of 40 genes included in the 5 critical pathways of CRC (WNT, P53, RTK-RAS, phosphatidylinositol-4,5-bisphosphate 3-kinase [PI3K], and transforming growth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28513830
DOI: 10.1002/cncr.30760

Genes

APC
BRAF
KRAS
NRAS

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