Hard wiring of normal tissue-specific chromosome-wide gene expression levels is an additional factor driving cancer type-specific aneuploidies.

doi:10.1186/s13073-021-00905-y

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Article

Hard wiring of normal tissue-specific chromosome-wide gene expression levels is an additional factor driving cancer type-specific aneuploidies.

Genome medicine - 25 May 2021

Patkar Sushant, Heselmeyer-Haddad Kerstin, Auslander Noam, Hirsch Daniela, Camps Jordi, Bronder Daniel, Brown Markus, Chen Wei-Dong, Lokanga Rachel, Wangsa Darawalee, Wangsa Danny, Hu Yue, Lischka Annette, Braun Rüdiger, Emons Georg, Ghadimi B Michael, Gaedcke Jochen, Grade Marian, Montagna Cristina, Lazebnik Yuri, Difilippantonio Michael J, Habermann Jens K, Auer Gert, Ruppin Eytan, Ried Thomas

Abstract excerpt

BACKGROUND: Many carcinomas have recurrent chromosomal aneuploidies specific to the tissue of tumor origin. The reason for this specificity is not completely understood. METHODS: In this study, we looked at the frequency of chromosomal arm gains and losses in different cancer types from the The Cancer Genome Atlas (TCGA) and compared them to the mean gene expression of each chromosome arm in corresponding normal...

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PMID: 34034815
DOI: 10.1186/s13073-021-00905-y
PMCID: PMC8147418

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