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Pan-cancer analysis of single-cell RNA sequencing data from 304 human tumors sheds light on the ‘aneuploidy paradox’

2026-05-11

Abstract excerpt

Aneuploidy poses a central paradox in cancer biology: it impairs cellular fitness in normal cells but drives cancer progression. To resolve this, we analyzed single cell transcriptomes from >665,000 cells – including ∼288,000 malignant cells – across 304 tumors and 15 cancer types. Integrating transcriptomics with inferred aneuploidy profiles, we characterized cell-intrinsic programs and interactions with the tumo...

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Literature Corpus work
77746bdb-e873-558c-8ea8-1d9adaf356c5
DOI
10.64898/2026.05.06.723237
Open publication

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Pan-cancer analysis of single-cell RNA sequencing data from 304 human tumors sheds light on the ‘aneuploidy paradox’DOI 10.64898/2026.05.06.723237
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