Article
Pan-cancer patterns of somatic copy number alteration.
Nature genetics - 1 Oct 2013
Zack Travis I, Schumacher Stephen E, Carter Scott L, Cherniack Andre D, Saksena Gordon, Tabak Barbara, Lawrence Michael S, Zhsng Cheng-Zhong, Wala Jeremiah, Mermel Craig H, Sougnez Carrie, Gabriel Stacey B, Hernandez Bryan, Shen Hui, Laird Peter W, Getz Gad, Meyerson Matthew, Beroukhim Rameen
Abstract excerpt
Determining how somatic copy number alterations (SCNAs) promote cancer is an important goal. We characterized SCNA patterns in 4,934 cancers from The Cancer Genome Atlas Pan-Cancer data set. Whole-genome doubling, observed in 37% of cancers, was associated with higher rates of every other type of SCNA, TP53 mutations, CCNE1 amplifications and alterations of the PPP2R complex. SCNAs that were internal to...
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