Integrating mutation, copy number, and gene expression data to identify driver genes of recurrent chromosome-arm losses.

Abstract excerpt

Aneuploidy is a hallmark of cancer, yet the genes driving recurrent chromosome-arm losses remain largely unknown. We present a systematic framework integrating mutation, copy number, and gene expression data to identify candidate driver genes of cancer type-specific recurrent chromosome-arm losses across 20 cancer types, using ∼7,500 tumors from The Cancer Genome Atlas. By analyzing focal deletions and point...

Topics

• Humans
• Mutation
• Neoplasms
• DNA Copy Number Variations
• Gene Expression Regulation, Neoplastic
• Chromosome Deletion