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Selection forces underlying aneuploidy patterns in cancer

24 Jun 2024

Abstract excerpt

Aneuploidy, the presence of an aberrant number of chromosomes, has been associated with tumorigenesis for over a century. More recently, advances in karyotyping techniques have revealed its high prevalence in cancer: About 90% of solid tumors and 50-70% of hematopoietic cancers exhibit chromosome gains or losses. When analyzed at the level of specific chromosomes, there are strong patterns that are observed in...

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PMID: 38919375
DOI: 10.1080/23723556.2024.2369388

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