Article

Integrating gene expression, mutation and copy number data to identify driver genes of recurrent chromosome-arm losses

2025-02-27

Abstract excerpt

Aneuploidy is a hallmark of cancer, yet the specific genes driving recurrent chromosome-arm losses remain largely unknown. Here, we present a systematic framework integrating gene expression, mutation, and copy number data to identify candidate driver genes of cancer type-specific recurrent chromosome-arm losses across 20 cancer types, using ∼7,500 tumors from The Cancer Genome Atlas. By analyzing focal deletions...

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Literature Corpus work: 7eb530c2-3865-530f-9f06-47494fccac72
DOI: 10.1101/2025.02.22.639659

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