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Article

Genetic predisposition, Aβ misfolding in blood plasma, and Alzheimer's disease.

Translational psychiatry - 1 May 2021

Stocker Hannah, Nabers Andreas, Perna Laura, Möllers Tobias, Rujescu Dan, Hartmann Annette M, Holleczek Bernd, Schöttker Ben, Stockmann Julia, Gerwert Klaus, Brenner Hermann

Abstract excerpt

Alzheimer's disease is highly heritable and characterized by amyloid plaques and tau tangles in the brain. The aim of this study was to investigate the association between genetic predisposition, Aβ misfolding in blood plasma, a unique marker of Alzheimer associated neuropathological changes, and Alzheimer's disease occurrence within 14 years. Within a German community-based cohort, two polygenic risk scores...

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Identifiers

PMID: 33934115
DOI: 10.1038/s41398-021-01380-0
PMCID: PMC8088439

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