Article
A Non-APOE Polygenic Risk Score for Alzheimer's Disease Is Associated With Cerebrospinal Fluid Neurofilament Light in a Representative Sample of Cognitively Unimpaired 70-Year Olds.
The journals of gerontology. Series A, Biological sciences and medical sciences - 22 May 2021
Skoog Ingmar, Kern Silke, Najar Jenna, Guerreiro Rita, Bras Jose, Waern Margda, Zetterberg Henrik, Blennow Kaj, Zettergren Anna
Abstract excerpt
The effect of Alzheimer's disease (AD) polygenic risk scores (PRS) on amyloid and tau pathophysiology and neurodegeneration in cognitively unimpaired older adults is not known in detail. This study aims to investigate non-APOE AD-PRS and APOE ε4 in relation to AD pathophysiology evaluated by cerebrospinal fluid (CSF) biomarkers in a population-based sample of 70-year olds. A total of 303 dementia-free individuals...
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