Article
A 22-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid Aβ42.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Dec 2015
Sleegers Kristel, Bettens Karolien, De Roeck Arne, Van Cauwenberghe Caroline, Cuyvers Elise, Verheijen Jan, Struyfs Hanne, Van Dongen Jasper, Vermeulen Steven, Engelborghs Sebastiaan, Vandenbulcke Mathieu, Vandenberghe Rik, De Deyn Peter Paul, Van Broeckhoven Christine
Abstract excerpt
INTRODUCTION: The ability to identify individuals at increased genetic risk for Alzheimer's disease (AD) may streamline biomarker and drug trials and aid clinical and personal decision making. METHODS: We evaluated the discriminative ability of a genetic risk score (GRS) covering 22 published genetic risk loci for AD in 1162 Flanders-Belgian AD patients and 1019 controls and assessed correlations with family...
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