Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer.

doi:10.1038/s42003-021-01842-7

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Article

Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer.

Communications biology - 9 Mar 2021

Cai Ling, Liu Hongyu, Huang Fang, Fujimoto Junya, Girard Luc, Chen Jun, Li Yongwen, Zhang Yu-An, Deb Dhruba, Stastny Victor, Pozo Karine, Kuo Christin S, Jia Gaoxiang, Yang Chendong, Zou Wei, Alomar Adeeb, Huffman Kenneth, Papari-Zareei Mahboubeh, Yang Lin, Drapkin Benjamin, Akbay Esra A, Shames David S, Wistuba Ignacio I, Wang Tao, Johnson Jane E, Xiao Guanghua, DeBerardinis Ralph J, Minna John D, Xie Yang, Gazdar Adi F

Abstract excerpt

Small cell lung cancer (SCLC) is classified as a high-grade neuroendocrine (NE) tumor, but a subset of SCLC has been termed "variant" due to the loss of NE characteristics. In this study, we computed NE scores for patient-derived SCLC cell lines and xenografts, as well as human tumors. We aligned NE properties with transcription factor-defined molecular subtypes. Then we investigated the different immune...

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Identifiers

PMID: 33750914
DOI: 10.1038/s42003-021-01842-7
PMCID: PMC7943563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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