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Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer

23 Jun 2021

Abstract excerpt

Immune checkpoint blockade (ICB) benefits only a small subset of patients with small cell lung cancer (SCLC), yet the mechanisms driving benefit are poorly understood. To identify predictors of clinical benefit to ICB, we performed immunogenomic profiling of tumor samples from patients with relapsed SCLC. Tumors of patients who derive clinical benefit from ICB exhibit cytotoxic T-cell infiltration, high...

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PMID: 34162872
DOI: 10.1038/s41467-021-24164-y

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