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Article

Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes

1 Feb 2018

Abstract excerpt

Background: Small cell lung cancer (SCLC) is a deadly, high grade neuroendocrine (NE) tumor without recognized morphologic heterogeneity. However, over 30 years ago we described a SCLC subtype with “variant” morphology which did not express some NE markers and exhibited more aggressive growth. Methods: To quantitate NE properties of SCLCs, we developed a 50-gene expression-based NE score that could be applied to...

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PMID: 29535911
DOI: 10.21037/tlcr.2018.02.02

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