Article
Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models
19 Apr 2022
Abstract excerpt
Molecular subtypes of small cell lung cancer (SCLC) defined by the expression of key transcription regulators have recently been proposed in cell lines and limited number of primary tumors. The clinical and biological implications of neuroendocrine (NE) subtypes in metastatic SCLC, and the extent to which they vary within and between patient tumors and in patient-derived models is not known. We integrate...
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