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The small cell lung cancer neuroendocrine transdifferentiation explorer

2022-08-02

Abstract excerpt

SCLC is a high-grade neuroendocrine (NE) cancer that exhibits cellular plasticity. Transdifferention into non-NE cells creates considerable intra-tumoral heterogeneity, enhanced metastasis, greater tumor burden, and treatment resistance. Similar NE transdifferentiation has been observed in neuroblastoma (NBL). Targeting NE plasticity and cooperation between NE and non-NE cells in the tumor microenvironment may pro...

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Literature Corpus work
3fa3404a-6492-5d0d-b2b8-3f0ec63bb70e
DOI
10.1101/2022.08.01.502252
Open publication

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