Transcriptomic profiling of lineage transformation and actionable therapy opportunities in EGFR-mutant non-small cell lung cancer evolving to small cell lung cancer.

doi:10.1186/s12967-026-08853-0

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Article

Transcriptomic profiling of lineage transformation and actionable therapy opportunities in EGFR-mutant non-small cell lung cancer evolving to small cell lung cancer.

Journal of translational medicine - 28 Aug 2026

Yu Hui, Li Meichen, Li Xiaodie, Yu Mingjie, Pan Yin, Yun Jingping, Chen Likun

Abstract excerpt

BACKGROUND: Neuroendocrine transformation of epidermal growth factor receptor-mutant lung adenocarcinoma (EGFRm LUAD) represents a significant mechanism underlying acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). This histological transformation lacks effective treatments. We comprehensively discussed the treatments of transformed small cell lung cancer (T-SCLC) and analyzed the transcriptomic...

Read the complete abstract on PubMed

Topics

Humans
Lung Neoplasms
Mutation
Small Cell Lung Carcinoma
Gene Expression Profiling
ErbB Receptors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Carcinoma, Non-Small-Cell Lung

Female

Male

Gene Expression Regulation, Neoplastic

Cell Lineage

Cell Transformation, Neoplastic

Aged

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 42681635
DOI: 10.1186/s12967-026-08853-0

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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