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Article

Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility.

Nature communications - 3 Mar 2021

Spichal Maya, Heestand Bree, Billmyre Katherine Kretovich, Frenk Stephen, Mello Craig C, Ahmed Shawn

Abstract excerpt

In several species, Piwi/piRNA genome silencing defects cause immediate sterility that correlates with transposon expression and transposon-induced genomic instability. In C. elegans, mutations in the Piwi-related gene (prg-1) and other piRNA deficient mutants cause a transgenerational decline in fertility over a period of several generations. Here we show that the sterility of late generation piRNA mutants...

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Identifiers

PMID: 33658512
DOI: 10.1038/s41467-021-21635-0
PMCID: PMC7930041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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