Article
ELLI-1, a novel germline protein, modulates RNAi activity and P-granule accumulation in Caenorhabditis elegans.
PLoS genetics - 1 Feb 2017
Andralojc Karolina M, Campbell Anne C, Kelly Ashley L, Terrey Markus, Tanner Paige C, Gans Ian M, Senter-Zapata Michael J, Khokhar Eraj S, Updike Dustin L
Abstract excerpt
Germ cells contain non-membrane bound cytoplasmic organelles that help maintain germline integrity. In C. elegans they are called P granules; without them, the germline undergoes partial masculinization and aberrant differentiation. One key P-granule component is the Argonaute CSR-1, a small-RNA binding protein that antagonizes accumulation of sperm-specific transcripts in developing oocytes and fine-tunes...
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