Article

Germ Granules Coordinate RNA-based Epigenetic Inheritance Pathways

2019-07-18

Abstract excerpt

Germ granules are biomolecular condensates that promote germ cell totipotency in most, if not all, animals. In C. elegans , MEG-3 and MEG-4 are two intrinsically disordered proteins that are redundantly required for the phase separations that drive germ granule assembly in germline blastomeres. Here, we show that animals lacking MEG-3/4 exhibit defects in dsRNA-mediated gene silencing (RNAi) that are due, at leas...

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Literature Corpus work: 3a9f6471-f431-5867-b104-0b253d279861
DOI: 10.1101/707596

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