Article

Piwi mutant germ cells transmit a form of heritable stress that promotes longevity

2018-05-19

Abstract excerpt

<h4>Summary</h4> The C. elegans Argonaute protein PRG-1/Piwi and associated piRNAs protect metazoan genomes by silencing transposons and other types of foreign DNA. As prg-1 mutants are propagated, their fertility deteriorates prior to the onset of a reproductive arrest phenotype that resembles a starvation-induced stress response. We found that late-generation prg-1 mutants with substantially reduced fertilit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 317a9cfe-6dcb-51e1-b422-e57ec59f90f1
DOI: 10.1101/326769

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Piwi mutant germ cells transmit a form of heritable stress that promotes longevityDOI 10.1101/326769Read

Piwi mutant germ cells transmit a form of heritable stress that promotes longevity.Semantic proximity Read

A reproductive arrest program triggered by defects in Piwi and germ granulesSemantic proximity Read

Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility.Semantic proximity Read

DAF-16/Foxo suppresses the transgenerational sterility of <i>prg-1</i> piRNA mutants via a systemic small RNA pathwaySemantic proximity Read

P granules protect RNA interference genes from silencing by piRNAsSemantic proximity Read

A Hypoxia Sensitive to Hypoxia Resistant Transformation in Long-Lived Germline MutantsSemantic proximity Read

C. elegans pro-1 activity is required for soma/germline interactions that influence proliferation and differentiation in the germ line.Semantic proximity Read

AMX-1 is necessary for proper fertility and lack of its expression induced sterility in a p53/CEP-1 dependent manner by modulating piwi expression in C. elegansSemantic proximity Read

Heat stress-induced condensation of G3BP1 in perinuclear P-bodies in <i>C. elegans’</i> germlineSemantic proximity Read

Germ Granules Functions are Memorized by Transgenerationally Inherited Small RNAsSemantic proximity Read

Construction of a germline-specific RNAi tool in <i>C. elegans</i>Semantic proximity Read

DAF-12 germline-to-soma signaling mediates transgenerational longevity in <i>C. elegans</i>Semantic proximity Read