Article

P granules protect RNA interference genes from silencing by piRNAs

2019-07-18

Abstract excerpt

<h4>SUMMARY</h4> P granules are perinuclear condensates in C. elegans germ cells proposed to serve as hubs for self/non-self RNA discrimination by Argonautes. We report that a mutant ( meg-3 meg-4 ) that does not assemble P granules in primordial germ cells loses competence for RNA-interference over several generations and accumulates silencing small RNAs against hundreds of endogenous genes, including the RNA-...

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Literature Corpus work: ed3a308f-b27f-5a89-b5d7-3c67943ab866
DOI: 10.1101/707562

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