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Article

Piwi mutant germ cells transmit a form of heritable stress that promotes longevity.

Aging cell - 1 Jan 2025

Heestand Bree, McCarthy Ben, Simon Matt, Lister-Shimauchi Evan H, Frenk Stephen, Ahmed Shawn

Abstract excerpt

The C. elegans Argonaute protein PRG-1/Piwi and associated piRNAs protect metazoan genomes by silencing transposons and other types of foreign DNA. As prg-1 mutants are propagated, their fertility deteriorates prior to the onset of a reproductive arrest phenotype that resembles a starvation-induced stress response. We found that late-generation prg-1 mutants with substantially reduced fertility were long-lived,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39520150
DOI: 10.1111/acel.14350
PMCID: PMC11709112

Genes

F2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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