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Chromatin architecture reveals cell type-specific target genes for kidney disease risk variants

24 Feb 2021

Abstract excerpt

BACKGROUND: Cell type-specific transcriptional programming results from the combinatorial interplay between the repertoire of active regulatory elements. Disease-associated variants disrupt such programming, leading to altered expression of downstream regulated genes and the onset of pathological states. However, due to the non-linear regulatory properties of non-coding elements such as enhancers, which can...

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PMID: 33627123
DOI: 10.1186/s12915-021-00977-7

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