Article
Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets.
Nature communications - 15 Apr 2021
Miao Zhen, Balzer Michael S, Ma Ziyuan, Liu Hongbo, Wu Junnan, Shrestha Rojesh, Aranyi Tamas, Kwan Amy, Kondo Ayano, Pontoglio Marco, Kim Junhyong, Li Mingyao, Kaestner Klaus H, Susztak Katalin
Abstract excerpt
Determining the epigenetic program that generates unique cell types in the kidney is critical for understanding cell-type heterogeneity during tissue homeostasis and injury response. Here, we profile open chromatin and gene expression in developing and adult mouse kidneys at single cell resolution. We show critical reliance of gene expression on distal regulatory elements (enhancers). We reveal key cell...
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